Sothoros is a death metal band from Athens, Ohio, formed in 2010, crafting punishing and straightforward death metal within a small-city underground scene built around Ohio University.

Soul Realignment is a death metal band from Cincinnati, Ohio, formed in 2026. A nascent act from Ohio's underground, they pursue the punishing sonic territory of straight-ahead death metal.

Soulless is a Cleveland, Ohio melodic death and thrash metal band with roots stretching back to 1998. One of Ohio's longer-running extreme metal acts, they combine the melodic sensibility of Swedish-influenced death metal with thrash's technical aggression.

Sourblood is a thrash metal band from Columbus, Ohio, formed in 2021, trafficking in the hard-hitting, velocity-driven riff work that connects them to both the classic thrash canon and the contemporary underground revival.

Southern Tongues is an Ohio death metal and hardcore band formed in 2019, bringing the visceral collision of extreme metal and hardcore aggression that defined bands working the boundary between the two genres in the American underground.

Space Monkey is a metalcore outfit from Cleveland, Ohio, formed in 2018. They operate within the aggressive riff-driven sound of the Midwest metalcore scene, blending heavy breakdowns with melodic sensibility.

SpaceCore is a Cleveland, Ohio band formed in 2024, working in experimental and psychedelic heavy metal. A recently formed outfit, they bring an exploratory approach to the genre, applying unconventional structures and textures to a foundation of traditional heavy metal.

Sparrowmilk is a doom and sludge metal band from Cleveland, Ohio, formed in 2017, trafficking in the city's tradition of slow, oppressive heaviness with droning riffs and suffocating atmosphere.

Spellchucker is a doom/sludge metal band from Cleveland, Ohio, formed in 2018, delivering slow, oppressively heavy music that fuses traditional doom's despair with sludge metal's abrasive, feedback-drenched textures.